Mink J T, Gerrard J W, Cockcroft D W, Cotton D J, Dosman J A
Chest. 1980 Jan;77(1):28-31. doi: 10.1378/chest.77.1.28.
We measured nonspecific bronchial reactivity to inhaled histamine in 26 lifetime nonsmoking grain handlers and 29 lifetime nonsmoking unexposed control subjects matched for age, sex and specific conductance. Routine lung function tests revealed a total lung capacity that was higher in control subjects than in workers (P less than 0.05) with no difference in other subdivisions of lung volume, or expiratory flow rates between the two groups. An index of allergy was significantly greater in the control subjects than in the grain workers (P less than 0.01). None of the grain handlers was sensitive to grain dust by history or by skin tests. Respiratory symptoms (cough, sputum, dyspnea, or wheezing) were more prevalent in the grain workers than in controls (P less than 0.05). The mean concentration of histamine required to reduce the specific conductance by 35 percent was 4.5 +/- 2.0 mg/ml in grain workers and 5.9 +/- 3.0 mg/ml in controls (P less than 0.05). Chronic exposure to grain dust in nonallergic individuals appears to be associated with both increased prevalence of respiratory symptoms and increased nonspecific bronchial reactivity when compared to nonexposed control subjects.
我们对26名终生不吸烟的谷物装卸工人和29名年龄、性别及比电导相匹配的终生不吸烟的未接触对照组受试者，测量了其对吸入组胺的非特异性支气管反应性。常规肺功能测试显示，对照组受试者的肺总量高于工人（P<0.05），两组在肺容积的其他细分指标或呼气流量方面无差异。对照组受试者的过敏指数显著高于谷物工人（P<0.01）。通过病史或皮肤试验，没有一名谷物装卸工人对谷物粉尘敏感。谷物工人中呼吸道症状（咳嗽、咳痰、呼吸困难或喘息）比对照组更普遍（P<0.05）。使比电导降低35%所需的组胺平均浓度，谷物工人为4.5±2.0mg/ml，对照组为5.9±3.0mg/ml（P<0.05）。与未接触的对照组受试者相比，非过敏个体长期接触谷物粉尘似乎与呼吸道症状患病率增加和非特异性支气管反应性增加均有关。
