Cookson W O, Ryan G, MacDonald S, Musk A W
Br J Ind Med. 1986 Jun;43(6):396-400. doi: 10.1136/oem.43.6.396.
One hundred and five young subjects with little or no previous exposure to grain dust were studied before and after a seven week period of grain handling work to determine if there was an association between symptoms experienced at work and pre-employment respiratory symptoms, allergy skin test responses, and non-allergic bronchial reactivity. The incidence of work related symptoms was cough 18%, wheeze 13%, and dyspnoea 14%. The results showed that pre-employment history of respiratory symptoms, positive allergy skin test responses, and a high level of non-allergic bronchial reactivity were significantly associated with these symptoms. These measurements may be useful to predict symptoms associated with exposure to grain dust in new employees and the results suggest that these work related symptoms may be due to allergen induced asthma.
105名此前很少或未曾接触谷物粉尘的年轻受试者，在从事为期7周的谷物处理工作前后接受了研究，以确定工作中出现的症状与入职前的呼吸道症状、过敏皮肤试验反应及非过敏性支气管反应性之间是否存在关联。与工作相关症状的发生率分别为咳嗽18%、喘息13%、呼吸困难14%。结果显示，入职前的呼吸道症状病史、过敏皮肤试验反应呈阳性以及高水平的非过敏性支气管反应性与这些症状显著相关。这些测量方法可能有助于预测新员工接触谷物粉尘后出现的症状，结果表明这些与工作相关的症状可能是由变应原诱发的哮喘所致。
