Wechsler J G, Ditschuneit H H, Malfertheiner P, Ditschuneit H
Dtsch Med Wochenschr. 1980 Jan 11;105(2):58-61. doi: 10.1055/s-2008-1070605.
Protein-substituted or protein-saving modified fasting (PSMF) is intended to prevent high protein loss during total fasting by use of low-dose substitution. 27 obese in-patients were treated over a period of four weeks with modified fasting. The daily amount of protein substituted was 33 g on an egg-white base (Modifast). As in total fasting the nitrogen balance of the first and second week was negative, balanced in the third week and positive in the fourth. The total balance over 4 weeks was negative with a nitrogen loss of 70.7 g N, equivalent to a protein loss of 442 g (lean body mass). Nitrogen and protein loss in PSMF over 4 weeks was only a third of the loss in total fasting (-183.2 g N equivalent to 1145 g protein). Protein-substituted modified fasting may be used for more than 4 weeks as nitrogen balance is stabilised as from the third week, and remained so until the end of the observation period of 8 weeks.
蛋白质替代或蛋白质节省型改良禁食（PSMF）旨在通过低剂量替代来防止全禁食期间的高蛋白损失。27名肥胖住院患者接受了为期四周的改良禁食治疗。以蛋清为基础（Modifast），每日替代的蛋白质量为33克。与全禁食一样，第一周和第二周的氮平衡为负，第三周平衡，第四周为正。四周的总平衡为负，氮损失70.7克，相当于蛋白质损失442克（去脂体重）。PSMF四周的氮和蛋白质损失仅为全禁食损失的三分之一（-183.2克氮相当于1145克蛋白质）。蛋白质替代改良禁食可使用超过四周，因为从第三周起氮平衡就稳定了，并且在长达8周的观察期结束时一直保持稳定。
