Ehrengut W, Lennartz H
Dtsch Med Wochenschr. 1980 Feb 1;105(5):153-4. doi: 10.1055/s-2008-1070624.
Recent rubella infection (rubella-specific IgM positive, raised rubella complement fixation reaction and haemagglutination inhibition) could be demonstrated during a prophylactic investigation in early pregnancy in a 19-year-old girl previously successfully immunised with Cendehill vaccine (seroconversion). Due to the seroconversion demonstrated during school age no interruption was performed. The newborn baby had a rubella-HAI-antibody titre in the umbilical blood of 1 : 640, but no rubella-specific IgM antibodies (also at later controls). Rubella infection of the child in utero could thud be excluded. This for the first time confirms the protective effect of the Cendehill vaccine in the prophylaxis of rubella embryopathy.
在对一名19岁女孩进行的孕早期预防性检查中,发现其近期感染风疹(风疹特异性IgM阳性,风疹补体结合反应和血凝抑制试验结果升高)。该女孩此前成功接种了森德希尔疫苗(血清转化)。由于学龄期出现了血清转化,所以未采取中断措施。新生儿脐血中风疹血凝抑制抗体滴度为1:640,但未检测到风疹特异性IgM抗体(后续检查也是如此)。因此可以排除胎儿在子宫内感染风疹的情况。这首次证实了森德希尔疫苗在预防风疹胚胎病方面的保护作用。