Lewensohn R, Ringborg U
Blood. 1980 Feb;55(2):311-6.
Unscheduled DNA synthesis (UDS) induced by melphalan, nitrogen mustard and ultra-violet irradiation was studied in bone marrow cells from myeloma patients. In a previous study, normal bone marrow cells in various stages of maturation were found to display a gradual decrease in UDS parallel with the process of maturation. Myeloma cells showed a similar pattern. Poorly differentiated myeloma cells exhibited a similar level of UDS to myeloblasts and erythroblasts. Irrespective of which repair-inducing agent was used, the relationship between the levels of UDS in the various cell types was constant. This indicates that the differences in the level of UDS in the various cell types was not due to differences in the uptake of the repair-inducing agent.
研究了美法仑、氮芥和紫外线照射诱导骨髓瘤患者骨髓细胞的非计划DNA合成（UDS）情况。在先前的一项研究中，发现处于不同成熟阶段的正常骨髓细胞，其UDS水平会随着成熟过程逐渐降低。骨髓瘤细胞呈现出类似的模式。低分化骨髓瘤细胞的UDS水平与成髓细胞和成红细胞相似。无论使用哪种诱导修复的试剂，不同细胞类型中UDS水平之间的关系都是恒定的。这表明不同细胞类型中UDS水平的差异并非由于诱导修复试剂摄取的差异所致。
