Zhu Z, Parviainen M, Männistö S, Pietinen P, Eskelinen M, Syrjänen K, Uusitupa M
Department of Clinical Nutrition, University of Kuopio, Finland.
Cancer Causes Control. 1996 Nov;7(6):591-5. doi: 10.1007/BF00051701.
Previous data on animals and humans suggest that vitamin E may be a protective factor against cancer. A low dietary vitamin E intake has been suggested to increase the risk of breast cancer. We examined the dietary intake and the concentration of vitamin E in breast adipose tissue of women in Kuopio, Finland, diagnosed between 1990 and 1992 with benign breast disease (n = 34) and with breast cancer (n = 32). In postmenopausal women, lower dietary intake (P = 0.006) and a smaller concentration of vitamin E in breast adipose tissue (P = 0.024) were observed in breast cancer patients than in subjects with benign breast disease. Partial correlation showed that the vitamin E concentration in the breast adipose tissue correlated positively with the dietary intake of vitamin E (r = 0.25, P = 0.023), indicating that the vitamin E concentration in breast adipose tissue reflects the dietary intake of vitamin E.
先前关于动物和人类的数据表明，维生素E可能是预防癌症的保护因素。有人提出，饮食中维生素E摄入量低会增加患乳腺癌的风险。我们调查了1990年至1992年间在芬兰库奥皮奥被诊断为患有良性乳腺疾病（n = 34）和乳腺癌（n = 32）的女性的饮食摄入量以及乳腺脂肪组织中维生素E的浓度。在绝经后女性中，与患有良性乳腺疾病的受试者相比，乳腺癌患者的饮食摄入量较低（P = 0.006），乳腺脂肪组织中维生素E的浓度也较低（P = 0.024）。偏相关分析表明，乳腺脂肪组织中维生素E的浓度与维生素E的饮食摄入量呈正相关（r = 0.25，P = 0.023），这表明乳腺脂肪组织中维生素E的浓度反映了维生素E的饮食摄入量。
