Havlik R J, Garrison R J, Feinleib M, Padgett S, Castelli W P, McNamara P M
Circulation. 1980 Apr;61(4):710-5. doi: 10.1161/01.cir.61.4.710.
The offspring of parents belonging to the original Framingham Heart Study cohort, and spouses of these offspring, were examined beginning in 1971. Cardiovascular examinations similar to those performed on the parents in 1952-1953 were given to offspring and their spouses. The mean blood pressure (BP) appeared to be lower in the female offspring-spouses than in the cohort mothers. Comparable multivariate analyses on 3588 offspring and spouses of both sexes, ages 20-49 years, and 1842 parents, ages 30-49 years, confirmed the frequently reported importance of weight, heart rate, alcohol consumption, glucose and hematocrit or hemoglobin as independent positive correlates and smoking as an inverse correlate of botsured variables of total serum proteins and plasma triglycerides added significantly to prediction of BP in both sex groups, and a less striking negative association was found for serum phosphorus. The findings for serum proteins and triglycerides were supported in a separate population of middle-aged twin men. Even with the additional measured variables, only 28-34% of the total BP variance is explained in these populations.
属于最初弗雷明汉心脏研究队列的父母的后代，以及这些后代的配偶，从1971年开始接受检查。对后代及其配偶进行了与1952 - 1953年对父母进行的类似的心血管检查。女性后代配偶的平均血压似乎低于队列中的母亲。对3588名年龄在20 - 49岁的后代和配偶以及1842名年龄在30 - 49岁的父母进行的类似多变量分析证实，体重、心率、饮酒量、血糖和血细胞比容或血红蛋白作为独立的正相关因素，以及吸烟作为总血清蛋白和血浆甘油三酯相关变量的负相关因素，其重要性经常被报道。在两个性别组中，体重、心率、饮酒量、血糖和血细胞比容或血红蛋白作为独立的正相关因素，以及吸烟作为总血清蛋白和血浆甘油三酯相关变量的负相关因素，其重要性经常被报道。血清磷的负相关不太显著。血清蛋白和甘油三酯的研究结果在另一组中年男性双胞胎中得到了支持。即使有额外测量的变量，这些人群中总血压变异的解释率也仅为28 - 34%。
