T细胞和B细胞上个体Ia特异性的表达。I. 对丝裂原诱导的母细胞的研究。
Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells.
作者信息
David C, Meo T, McCormick J, Shreffler D
出版信息
J Exp Med. 1976 Jan 1;143(1):218-24. doi: 10.1084/jem.143.1.218.
Abstract
Ia specificities 1-10 were detected on LPS-stimulated splenic lymphocytes and on Con A-stimulated spleen, lymph node, and thymus blasts by direct cytotoxic tests. Since Ia antigens are not readily detectable on resting thymocytes, our results suggest that T cells require some signal before they exhibit full expression of Ia specificities. Absorption-elution studies indicated that most of the Ia specificities detected on T and B cells may be identical. Ia antigens detected by homologous antisera gave much stronger reactions than those detected by cross-reacting antisera.
摘要
通过直接细胞毒性试验在脂多糖刺激的脾淋巴细胞以及刀豆蛋白A刺激的脾、淋巴结和胸腺母细胞上检测到Ia特异性1 - 10。由于静止胸腺细胞上不易检测到Ia抗原，我们的结果表明T细胞在充分表达Ia特异性之前需要某种信号。吸收 - 洗脱研究表明，在T细胞和B细胞上检测到的大多数Ia特异性可能是相同的。同源抗血清检测到的Ia抗原比交叉反应抗血清检测到的Ia抗原反应要强得多。
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J Exp Med. 1976 Jan 1;143(1):218-24. doi: 10.1084/jem.143.1.218.
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本文引用的文献
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Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.胸腺来源淋巴细胞上Ia（与H-2相关）抗原表达的证据。
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Serological identification of an Ir-region product.Ir区域产物的血清学鉴定。
Science. 1973 Jul 13;181(4095):167-9. doi: 10.1126/science.181.4095.167.
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New lymphocyte antigen system (Lna) controlled by the Ir region of the mouse H-2 complex.由小鼠H-2复合体的Ir区域控制的新淋巴细胞抗原系统（Lna）。
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2509-14. doi: 10.1073/pnas.70.9.2509.
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A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex.一种由与主要组织相容性复合体连锁的基因所决定的小鼠B细胞同种抗原。
J Exp Med. 1973 Dec 1;138(6):1289-304. doi: 10.1084/jem.138.6.1289.
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Histocompatibility-linked immune response genes.组织相容性连锁免疫反应基因
Science. 1972 Jan 21;175(4019):273-9. doi: 10.1126/science.175.4019.273.
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Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers.细胞协作中的抗原特异性T细胞因子。在H-2复合体I区内的定位及跨越同种异体屏障进行协作的能力。
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