监测动脉瘤性蛛网膜下腔出血后脑脊液中的纤溶活性：再出血风险的指南？
Monitoring fibrinolytic activity in the cerebrospinal fluid after aneurysmal subarachnoid haemorrhage: a guide to the risk of rebleeding?
作者信息
Maurice-Williams R S, Gordon Y B, Sykes A
出版信息
J Neurol Neurosurg Psychiatry. 1980 Feb;43(2):175-81. doi: 10.1136/jnnp.43.2.175.
Abstract
Serial assay of fibrin degradation products (FDPs) was used to monitor fibrinolytic activity in blood and cerebrospinal fluid (CSF) after subarachnoid haemorrhage (SAH) in 64 patients, 43 of whom had aneurysms. CSF levels fell rapidly from high initial values over a few days, thereafter more slowly to reach normal levels after one to six weeks. Probably only the later slow decline is a measure of fibrinolysis, which is obscured in the first few days by the cross antigenicity with FDP's of fibrinogen released by the bleed. After this phase of fibrinogen clearance, early attainment of normal FDP levels appears to be associated with a lower risk of rebleeding in cases of aneurysm. This phenomenon could be useful in deciding whether marginal cases should be treated surgically or conservatively.
摘要
采用连续测定纤维蛋白降解产物（FDPs）的方法，对64例蛛网膜下腔出血（SAH）患者血液和脑脊液（CSF）中的纤溶活性进行监测，其中43例患者患有动脉瘤。脑脊液水平在最初几天内从较高的初始值迅速下降，此后下降速度减慢，在1至6周后达到正常水平。可能只有后期的缓慢下降才是纤溶的指标，在最初几天，它被出血释放的纤维蛋白原与FDP的交叉抗原性所掩盖。在纤维蛋白原清除阶段之后，FDP水平早期恢复正常似乎与动脉瘤患者再出血风险较低有关。这一现象在决定边缘病例应采取手术治疗还是保守治疗时可能会有所帮助。
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Monitoring fibrinolytic activity in the cerebrospinal fluid after aneurysmal subarachnoid haemorrhage: a guide to the risk of rebleeding?监测动脉瘤性蛛网膜下腔出血后脑脊液中的纤溶活性：再出血风险的指南？
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