Pederson J E, Anderson D R
Arch Ophthalmol. 1980 Mar;98(3):490-5. doi: 10.1001/archopht.1980.01020030486010.
Serial disc photographs of 259 patients with elevated intraocular pressures were studied retrospectively up to 15 years. Twenty-nine eyes showed progressive enlargement of the optic cup. Early vertical extension of the cup occurred in vertical extension of the cup occurred in five eyes and horizontal extension in one. In 23 eyes, a generalized expansion of the cup (retaining its round appearance) was the first change observed, typically preceding visual field loss by several years. Thus, serial disc photographs are necessary for the earliest detection of optic nerve damage in ocular hypertension. Of 18 eyes with normal visual fields at the time progression of cupping was first noted, typical glaucomatous field loss developed in 50% during a follow-up of one to six years (average, two years). Therefore, treatment is indicated for eyes exhibiting progressive disc cupping, even in the absence of visual field defects.
对259例眼压升高患者的系列视盘照片进行了长达15年的回顾性研究。29只眼睛显示视杯逐渐扩大。5只眼睛出现视杯早期垂直扩展，1只眼睛出现水平扩展。在23只眼睛中，视杯的普遍扩大（保持圆形外观）是观察到的第一个变化，通常在视野丧失前几年出现。因此，系列视盘照片对于早期检测高眼压症中的视神经损伤是必要的。在首次注意到视杯扩大进展时视野正常的18只眼睛中，在1至6年（平均2年）的随访期间，50%出现了典型的青光眼性视野缺损。因此，即使没有视野缺损，对于出现进行性视盘凹陷的眼睛也应进行治疗。
