Csallany A S, Ayaz K L
Arch Environ Health. 1978 Nov-Dec;33(6):285-91. doi: 10.1080/00039896.1978.10667349.
Mice on diets deficient in vitamin E, normal diets, diets with high supplements of vitamin E, and diets supplemented with N, N'-diphenyl-p-phenylenediamine (DPPD) were continuously exposed to 0.5 ppm or to 1.0 ppm nitrogen dioxide (NO2) or to filtered room air from weaning to 18 months of age. The effects of NO2 exposure on body weights, tissue weights, survival rates, and tissue organic solvent soluble lipofuscin (age) pigment concentrations were examined. Vitamin E deficiency resulted in lower body weights by 18 months of age; exposure to NO2 further increased this weight loss. With the exception of the kidney, tissue weights were not affected by NO2 exposure. Mice exposed to NO2 had lower survival rates than unexposed control animals. Tissue organic solvent soluble lipofuscin pigment (LFP) concentrations in the uterus, lung, spleen, kidney, liver, brain, and heart were not afffected by NO2 exposure. Only in the liver did vitamin E deficiency lead to an increase in LFP concentration; it did not occur in any of the other tissues examined.
将缺乏维生素E的饮食、正常饮食、高剂量补充维生素E的饮食以及补充了N，N'-二苯基对苯二胺（DPPD）的饮食喂养的小鼠，从断奶到18月龄持续暴露于0.5 ppm或1.0 ppm的二氧化氮（NO2）或过滤后的室内空气中。检测了二氧化氮暴露对体重、组织重量、存活率和组织有机溶剂可溶性脂褐素（年龄）色素浓度的影响。维生素E缺乏导致18月龄时体重降低；暴露于二氧化氮会进一步加剧体重减轻。除肾脏外，组织重量不受二氧化氮暴露的影响。暴露于二氧化氮的小鼠存活率低于未暴露的对照动物。子宫、肺、脾、肾、肝、脑和心脏中的组织有机溶剂可溶性脂褐素色素（LFP）浓度不受二氧化氮暴露的影响。仅在肝脏中，维生素E缺乏会导致LFP浓度增加；在其他任何检测的组织中均未出现这种情况。
