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[烧伤犬血液中低分子肽对小鼠完整肝线粒体功能状态的影响]

[Effect of low-molecular peptides from the blood of burned dogs on the functional state of intact liver mitochondria in mice].

作者信息

Lifshits R I, Riabinin V E, Charnaia L F, Val'dman B M, Efimenko G P

出版信息

Vopr Med Khim. 1980 Jan-Feb;26(1):63-6.

PMID:7368629
Abstract

In presence of toxic low molecular peptides, isolated from blood of dogs with burns within 3-4 hrs after the injury, the following phenomena were observed in intact mouse liver mitochondria: decrease in calcium-accumulating ability of mitochondria, sheir irreversible swelling, decrease in the rate of oxygen utilization, decrease in coefficients of stimulation of respiration and of respiratory control, decrease in the rates of phosphorylation and of oxidative phosphorylation.

摘要

在从受伤后3 - 4小时的烧伤犬血液中分离出的有毒低分子肽存在的情况下,在完整的小鼠肝线粒体中观察到以下现象:线粒体钙积累能力下降、其不可逆肿胀、氧利用率降低、呼吸刺激系数和呼吸控制系数降低、磷酸化速率和氧化磷酸化速率降低。

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