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1
Isolation of the C-fragment and C'-fragment of lipotropin from pig pituitary and C-fragment from brain.从猪垂体中分离促脂解素的C片段和C'片段以及从脑中分离C片段。
Biochem J. 1978 Oct 1;175(1):261-70. doi: 10.1042/bj1750261.
2
Beta-endorphin-related peptides in the pituitary gland: isolation, identification and distribution.垂体中的β-内啡肽相关肽：分离、鉴定与分布。
Ciba Found Symp. 1981;81:79-96. doi: 10.1002/9780470720646.ch6.
3
Beta-endorphin-related peptides in the human pituitary. Isolation and characterization of major immunoreactive peptides, including the formerly unrecognized peptide beta-endorphin 1-18.人垂体中与β-内啡肽相关的肽。主要免疫反应性肽的分离与鉴定，包括之前未被识别的肽β-内啡肽1-18。
Acta Physiol Scand Suppl. 1984;531:1-84.
4
Isolation and characterization of the opioid peptides from rat pituitary: beta-lipotropin.从大鼠垂体中分离和鉴定阿片样肽：β-促脂素。
Proc Natl Acad Sci U S A. 1977 Jul;74(7):3052-5. doi: 10.1073/pnas.74.7.3052.
5
Isolation and properties of beta-endorphin-(1-27), N alpha-acetyl-beta-endorphin, corticotropin, gamma-lipotropin and neurophysin from equine pituitary glands.从马垂体中分离出β-内啡肽-（1-27）、Nα-乙酰-β-内啡肽、促肾上腺皮质激素、γ-促脂素和神经垂体素及其性质
Int J Pept Protein Res. 1981 Nov;18(5):443-50. doi: 10.1111/j.1399-3011.1981.tb03005.x.
6
Distribution of active and inactive forms of endorphins in rat pituitary and brain.内啡肽的活性和非活性形式在大鼠垂体和大脑中的分布。
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5972-6. doi: 10.1073/pnas.76.11.5972.
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Isolation of a COOH-terminal beta-lipotropin fragment (residues 61--91) with morphine-like analgesic activity from porcine pituitary glands.从猪垂体中分离出具有吗啡样镇痛活性的羧基末端β-促脂素片段（第61至91位氨基酸残基）。
Acta Biochim Biophys Acad Sci Hung. 1976;11(2-3):121-2.
8
Isolation and primary structure of beta-endrophin and beta-lipotropin from bovine pituitary glands.从牛垂体中分离β-内啡肽和β-促脂素及其一级结构
Biochem Biophys Res Commun. 1977 Aug 8;77(3):1088-93. doi: 10.1016/s0006-291x(77)80090-9.
9
Immunological characterization of beta-lipotropin fragments (endorphin, beta-MSH, and N-fragment) from fish pituitaries.鱼类垂体中β-促脂素片段（内啡肽、β-促黑素和N-片段）的免疫学特性分析
Gen Comp Endocrinol. 1978 Feb;34(2):163-8. doi: 10.1016/0016-6480(78)90207-1.
10
Isolation and characterization of beta-lipotropin and adrenocorticotropin from turkey pituitary glands.从火鸡脑垂体中分离并鉴定β-促脂解素和促肾上腺皮质激素。
Int J Pept Protein Res. 1980 Mar;15(3):261-70. doi: 10.1111/j.1399-3011.1980.tb02576.x.

引用本文的文献

1
Distribution of beta-endorphin-related peptides in rat pituitary and brain.β-内啡肽相关肽在大鼠垂体和脑中的分布。
Biochem J. 1982 Mar 15;202(3):561-71. doi: 10.1042/bj2020561.
2
beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia.β-内啡肽-（1-27）是β-内啡肽镇痛的拮抗剂。
Proc Natl Acad Sci U S A. 1984 Mar;81(5):1389-90. doi: 10.1073/pnas.81.5.1389.
3
Chemistry and biosynthesis of pro-opiomelanocortin. ACTH, MSH's, endorphins and their related peptides.促肾上腺皮质激素原的化学与生物合成。促肾上腺皮质激素、促黑素、内啡肽及其相关肽。
Mol Cell Biochem. 1981 Jan 28;34(2):101-27. doi: 10.1007/BF02354864.
4
Influence of N-terminal acetylation and C-terminal proteolysis on the analgesic activity of beta-endorphin.N 端乙酰化和 C 端蛋白水解对β-内啡肽镇痛活性的影响。
Biochem J. 1980 Sep 1;189(3):501-6. doi: 10.1042/bj1890501.
5
Isolation and characterization of beta-endorphin-like peptides from bovine brains.从牛脑中分离并鉴定β-内啡肽样肽
Proc Natl Acad Sci U S A. 1980 Jan;77(1):230-3. doi: 10.1073/pnas.77.1.230.
6
Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia.β-内啡肽-（1-27）是依托啡肽诱导镇痛的天然拮抗剂。
Proc Natl Acad Sci U S A. 1985 May;82(10):3178-81. doi: 10.1073/pnas.82.10.3178.
7
Distribution of active and inactive forms of endorphins in rat pituitary and brain.内啡肽的活性和非活性形式在大鼠垂体和大脑中的分布。
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5972-6. doi: 10.1073/pnas.76.11.5972.

本文引用的文献

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Preparation of iodine-131 labelled human growth hormone of high specific activity.高比活度碘-131标记人生长激素的制备
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2
The use of cyanate for the determination of NH2-terminal residues in proteins.用氰酸盐测定蛋白质中的氨基末端残基。
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Studies on the conversion of proinsulin to insulin. 3. Studies in vitro with a crude secretion granule fraction isolated from rat islets of Langerhans.胰岛素原向胰岛素转化的研究。3. 用从大鼠胰岛分离的粗分泌颗粒组分进行的体外研究。
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C fragment of lipotropin has a high affinity for brain opiate receptors.促脂解素的C片段对脑阿片受体具有高亲和力。
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A peptide-like substance from pituitary that acts like morphine. 2. Purification and properties.1. 一种来自垂体的、作用类似吗啡的肽样物质。2. 纯化及特性。
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Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine.从大脑中分离出一种具有与吗啡相似药理特性的内源性化合物。
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从猪垂体中分离促脂解素的C片段和C'片段以及从脑中分离C片段。

Isolation of the C-fragment and C'-fragment of lipotropin from pig pituitary and C-fragment from brain.

作者信息

Smyth D G, Snell C R, Massey D E

出版信息

Biochem J. 1978 Oct 1;175(1):261-70. doi: 10.1042/bj1750261.

DOI:10.1042/bj1750261
PMID:736896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1186062/
Abstract

Three novel peptides derived from lipotropin, the C-Fragment (residues 61-91), C'-Fragment (61-87) and N-Fragment (1-38), were isolated from pig pituitary, and the C-Fragment was shown to be present in brain. The experimental procedures developed for their isolation are described. The formation of each of the fragments involves enzymic cleavage of lipotropin at consecutive basic residues, with specificity identical with that involved in the activation of known prohormones. In brain assays C-Fragment exhibits a range of biological activities related to its ability to act as an inhibitory neurotransmitter.

摘要

从猪垂体中分离出了三种源自促脂素的新型肽，即C片段（第61 - 91位氨基酸残基）、C'片段（61 - 87位）和N片段（1 - 38位），并且发现C片段存在于大脑中。文中描述了为分离这些肽而开发的实验步骤。每个片段的形成都涉及促脂素在连续碱性残基处的酶促裂解，其特异性与已知激素原激活过程中涉及的特异性相同。在大脑检测中，C片段表现出一系列与其作为抑制性神经递质的作用能力相关的生物活性。