Rao N A, Hidayat A A, McLean I W, Zimmerman L E
Hum Pathol. 1982 Feb;13(2):113-22. doi: 10.1016/s0046-8177(82)80115-9.
One hundred four cases of sebaceous carcinoma that arose from ocular adnexa, with at least five years' follow-up information following diagnosis, were studied to extend the authors' previous observations on various prognostic factors in these tumors. Twenty-three patients died from metastatic disease. Although sebaceous carcinomas elsewhere in the skin are rare, this study establishes that these neoplasms occur much more frequently in the ocular adnexa and have significant morphologic features that identify the more highly lethal carcinomas. The various clinicopathologic features that indicated a bad prognosis were vascular, lymphatic, and orbital invasion; involvement of both upper and lower eyelids; poor differentiation; multicentric origin; duration of symptoms greater than six months; tumor diameter exceeding 10 mm; a highly infiltrative pattern; and pagetoid invasion of the overlying epithelia of the eyelids. In many cases pagetoid change appeared to originate in the underlying sebaceous glands and from there extended to invade the overlying epithelia.
对104例起源于眼附属器的皮脂腺癌进行了研究，这些病例在诊断后均有至少5年的随访信息，以扩展作者之前对这些肿瘤各种预后因素的观察。23例患者死于转移性疾病。尽管皮肤其他部位的皮脂腺癌很少见，但本研究证实这些肿瘤在眼附属器中更为常见，并且具有显著的形态学特征，可识别出更具致死性的癌。提示预后不良的各种临床病理特征包括血管、淋巴管和眼眶侵犯；上下眼睑均受累；分化差；多中心起源；症状持续时间超过6个月；肿瘤直径超过10 mm；高度浸润性生长方式；以及眼睑上皮的派杰样浸润。在许多病例中，派杰样改变似乎起源于下方的皮脂腺，然后从那里扩展至侵犯上方的上皮。
