Swerczek T W
Am J Vet Res. 1980 Mar;41(3):348-50.
Four experiments were performed to elucidate the pathogenesis of toxicoinfectious botulism in horses and foals. Groups of horses and foals were inoculated with one of the following: (1) crude toxin of Clostridium botulinum, type B, given IV, (2) C botulinum spores, given IM, (3) C botulinum spores, given IM, in necrotic lesions, and (4) C botulinum spores, given orally with and without dexamethasone. Toxin of C botulinum in minute amounts is toxic to horses. Clostridium botulinum spores produced toxicosis only when necrotic lesions were present. When C botulinum spores were given orally, they were innocuous. Toxicosis occurred when dexamethasone and C botulinum spores were given orally to a foal with necrotic lesions. Corticosteroids appear to predispose foals to the disease. In the animals where C botulinum organisms infected necrotic lesions, the clinical signs and the lesions seen on necropsy were identical with those seen in spontaneously occurring toxicoinfectious botulism.
进行了四项实验以阐明马和马驹中毒性感染性肉毒中毒的发病机制。将马和马驹分组并接种以下物质之一：(1)静脉注射B型肉毒梭菌粗毒素；(2)肌肉注射肉毒梭菌孢子；(3)在坏死病变处肌肉注射肉毒梭菌孢子；(4)口服肉毒梭菌孢子，同时或不同时给予地塞米松。微量的肉毒梭菌毒素对马有毒性。仅当存在坏死病变时，肉毒梭菌孢子才产生中毒。口服肉毒梭菌孢子时是无害的。当给有坏死病变的马驹口服地塞米松和肉毒梭菌孢子时会发生中毒。皮质类固醇似乎使马驹易患该病。在肉毒梭菌感染坏死病变的动物中，尸检时所见的临床症状和病变与自然发生的中毒性感染性肉毒中毒所见相同。
