Ando K, Hunter N, Peters L J
Br J Cancer. 1980 Feb;41(2):250-8. doi: 10.1038/bjc.1980.37.
A phenomenon by which pre-irradiation of the abdomen of mice reduced the lung-colony-forming efficiency of i.v.-injected tumour cells is described. The extent of lung-colony inhibition was shown to depend on both the dose and timing of abdominal irradiation. The maximum inhibitory effect was obtained when mice received 1200 rad gamma-irradiation to the abdomen 5--7 days before tumour-cell challenge, but there was no effect when abdominal irradiation was given 1 or greater than or equal to 14 days before challenge, or when radiation doses were less than 600 rad. In mice less than 3 weeks old, the effect was much less marked than in adults. The target tissue which, when irradiated, exerted the inhibitory influence on lung-colony formation was located in the ventral half of the abdomen in all 4 quadrants, and was probably gut. Radioactively labelled tumour cells were arrested normally in the lungs of irradiated mice, but were cleared more rapidly without evidence of sequestration in the irradiated gut. The most plausible mechanism seems to be that irradiation of the gut induces the production of natrual killer cells with anti-tumour activity, though this has not been conclusively established.
描述了一种现象，即对小鼠腹部进行预照射可降低经静脉注射的肿瘤细胞在肺部形成集落的效率。结果表明，肺部集落抑制的程度取决于腹部照射的剂量和时间。当小鼠在肿瘤细胞攻击前5 - 7天接受1200拉德的腹部γ射线照射时，可获得最大抑制效果，但当在攻击前1天或大于或等于14天进行腹部照射，或辐射剂量小于600拉德时，则无效果。在小于3周龄的小鼠中，这种效果比成年小鼠要弱得多。接受照射时，对肺部集落形成产生抑制作用的靶组织位于腹部的腹侧半区的所有4个象限，可能是肠道。放射性标记的肿瘤细胞在受照射小鼠的肺部正常滞留，但清除速度更快，且没有证据表明其在受照射的肠道中被隔离。最合理的机制似乎是肠道照射诱导产生具有抗肿瘤活性的自然杀伤细胞，尽管这一点尚未得到确凿证实。
