Stevens R H, Brooks G P, Osborne J W
Radiology. 1979 Jan;130(1):237-40. doi: 10.1148/130.1.237.
Exposure of only the ileum and jejunum of Holtzman male rats to 100--2000 R resulted in almost immediate and dose-dependent activation of anti-tumor cellular immune mechanisms, as measured in vitro by the cytotoxicity of the animals' peripheral blood lymphoid cells to allogeneic cultured cells from an x-irradiation induced Holtzman rat small bowel adenocarcinoma. These cytotoxic responses were somewhat specific; the lymphoid cells did not kill prostatic adenocarcinoma target cells and cytotoxicity could not be induced by x-irradiation of some tissues other than the small bowel. Results suggest that exposure of an organ to ionizing radiation results in changes which sensitize the lymphoid cells in the animal to recognize and kill cancer cells of the particular tissue. Immunologic suppression by ionizing radiation presumably did not occur because only a small portion of the body was exposed.
仅将霍尔茨曼雄性大鼠的回肠和空肠暴露于100 - 2000伦琴的辐射下，会导致抗肿瘤细胞免疫机制几乎立即且呈剂量依赖性地激活，这是通过体外测量动物外周血淋巴细胞对来自经x射线诱导的霍尔茨曼大鼠小肠腺癌的同种异体培养细胞的细胞毒性来确定的。这些细胞毒性反应具有一定的特异性；淋巴细胞不会杀死前列腺腺癌靶细胞，并且对小肠以外的某些组织进行x射线照射也不会诱导细胞毒性。结果表明，器官暴露于电离辐射会导致一些变化，使动物体内的淋巴细胞能够识别并杀死特定组织的癌细胞。由于仅身体的一小部分暴露，电离辐射大概并未导致免疫抑制。
