Eichholtz-Wirth H, Hietel B
Br J Cancer. 1986 Aug;54(2):239-43. doi: 10.1038/bjc.1986.168.
Clonogenic survival of HeLa, Chinese hamster and HaK cells after treatment with a range of cisplatin concentrations and exposure times was determined and cellular platinum concentrations were measured by PIXE. It was demonstrated that cisplatin cytotoxicity of the three cell lines varied considerably as a function of drug exposure dose. These differences are related to differential cellular drug uptake.
测定了用一系列顺铂浓度和暴露时间处理后,HeLa细胞、中国仓鼠细胞和HaK细胞的克隆形成存活率,并通过质子激发X射线发射(PIXE)测量细胞铂浓度。结果表明,三种细胞系的顺铂细胞毒性随药物暴露剂量的变化有很大差异。这些差异与细胞对药物摄取的差异有关。