Weihrauch T R, Vallerius P, Alpers H, Ewe K
Klin Wochenschr. 1980 Mar 17;58(6):287-92. doi: 10.1007/BF01476570.
In the second part of this study the effect of age, sex, body size, body weight and timing of the manometric examination (morning vs. noon) on esophageal pressure measurement was investigated in a total of 119 healthy subjects, using an electromagnetic microtransducer. Additionally intraindividual variation of pressures was studied over a period of 6 months. Of these parameters only age influenced upper esophageal sphincter (UES) pressure significantly: The mean UES pressure of younger subjects (20-49 years) was significantly higher (144.4 +/- 8.6 mmHg) compared to that of older subjects (50-80 years) where a mean pressure of 103.4 +/- 7.2 mmHg was recorded (p less than 0.0005). Intraindividual variation of pressures in the lower esophageal sphincter (LES) was considerable but exceeded only in a few cases the normal pressure range which was defined as M +/- 2 S. The results indicate that age, sex, different body weight and body size do not influence significantly the normal values obtained by a quantitative manometric method. In UES manometry however, the diminished resting pressure in the older patient must be taken into account.
在本研究的第二部分，使用电磁微型传感器，对总共119名健康受试者进行了研究，以探讨年龄、性别、体型、体重以及测压检查时间（早晨与中午）对食管压力测量的影响。此外，还在6个月的时间内研究了压力的个体内变化。在这些参数中，只有年龄对食管上括约肌（UES）压力有显著影响：较年轻受试者（20 - 49岁）的UES平均压力（144.4 +/- 8.6 mmHg）显著高于较年长受试者（50 - 80岁），后者记录的平均压力为103.4 +/- 7.2 mmHg（p < 0.0005）。食管下括约肌（LES）压力的个体内变化相当大，但仅在少数情况下超过了定义为M +/- 2S的正常压力范围。结果表明，年龄、性别、不同的体重和体型对通过定量测压法获得的正常值没有显著影响。然而，在进行UES测压时，必须考虑老年患者静息压力降低的情况。
