de Virgiliis S, Sanna G, Cornacchia G, Argiolu F, Murgia V, Porcu M, Cao A
Arch Dis Child. 1980 Jan;55(1):43-5. doi: 10.1136/adc.55.1.43.
Serum ferritin, liver iron stores, and liver histology were studied in 38 children with thalassaemia major who were being treated by regular blood transfusions. There was no correlation between serum ferritin levels and either the number of transfusions or the amount of iron deposited in the liver. However, for a given level of iron stores, ferritin levels were higher in patients with chronic hepatitis (including chronic aggressive and chronic persistent forms) than in those with hepatic siderosis only. We conclude that serum ferritin reflects tissue iron deposits in regularly transfused thalassaemic patients, only in the absence of hepatitis.
对38名接受定期输血治疗的重型地中海贫血患儿进行了血清铁蛋白、肝脏铁储存及肝脏组织学研究。血清铁蛋白水平与输血次数或肝脏中铁沉积量之间均无相关性。然而，对于给定的铁储存水平，慢性肝炎（包括慢性侵袭性和慢性持续性肝炎）患者的铁蛋白水平高于仅患有肝铁质沉着症的患者。我们得出结论，血清铁蛋白仅在无肝炎的情况下反映定期输血的地中海贫血患者的组织铁沉积。
