Bednár B, Trapl J
Cesk Patol. 1978 Nov;14(4):177-85.
In a female aged 83 who had been living in Prague for years, a bioptic diagnosis of rhinoscleroma was made. The disease responded well to Septrin treatment. Electron microscopical examination confirmed the histiocytic origin of Mikulicz cells, but cast doubt upon the belief that the large phagocytic cysts in such cells developed by confluence of smaller vacuoles. The examination revealed that the large cystic formations only contained Klebsiellae and a dense finely granular material identical with that of the bacterial capsiles. The small vacuoles found in the vicinity of the large ones never contained bacteria and their contents was either coarsely granular of finely filamentous. Therefore it rather corresponded to degradation products of the original content of the larger phagocytic cysts. The final picture of the Mikulicz cell are macrophages with only small light rounded vacuoles containing mucoid but no Klebsiellae.
在一位多年居住在布拉格的83岁女性身上，经活检诊断为鼻硬结病。该疾病对复方新诺明治疗反应良好。电子显微镜检查证实了米库利奇细胞的组织细胞起源，但对这样的细胞中大型吞噬性囊肿是由较小液泡融合形成的这一观点提出了质疑。检查发现，大型囊性结构仅含有克雷伯菌以及与细菌荚膜相同的致密细颗粒物质。在大型液泡附近发现的小液泡从未含有细菌，其内容物要么是粗颗粒状要么是细丝状。因此，它更像是较大吞噬性囊肿原始内容物的降解产物。米库利奇细胞的最终形态是巨噬细胞，只有小的浅色圆形液泡，含有黏液但没有克雷伯菌。
