低密度淋巴细胞的自发转化作为霍奇金病活动度的参数
Spontaneous transformation of low density lymphocytes as parameter of activity in Hodgkin's disease.
作者信息
de Pauw B E, de Mulder P H, Smeulders J B, Wagener D J, Haanen C
出版信息
Scand J Haematol. 1980 Jul;25(1):58-62. doi: 10.1111/j.1600-0609.1981.tb01365.x.
Analysis of spontaneous lymphocyte transformation, as measured by 3H-thymidine incorporation by low density lymphocytes, before and after therapy was performed in 28 patients with Hodgkin's disease. Before treatment increased 3H-thymidine uptake was found in 24 out of 28 patients. Following therapy the spontaneous lymphocyte transformation of the patients in clinical remission returned to the normal range, whereas none of the patients with residual disease achieved these levels. The overall correlation between the uptake of the DNA precursor by low density, lymphocytes and disease activity after treatment was excellent.
对28例霍奇金病患者治疗前后的自发性淋巴细胞转化进行了分析，通过低密度淋巴细胞掺入³H-胸腺嘧啶核苷来测定。治疗前，28例患者中有24例³H-胸腺嘧啶核苷摄取增加。治疗后，临床缓解患者的自发性淋巴细胞转化恢复到正常范围，而残留疾病患者无一达到这些水平。治疗后低密度淋巴细胞对DNA前体的摄取与疾病活动之间的总体相关性良好。
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