Paganelli R, Ngu J L, Levinsky R J
Clin Exp Immunol. 1980 Mar;39(3):570-5.
Circulating immune complexes were detected in sera of patients with both localized and generalized onchocerciasis by a 125I-Clq binding assay but not by the IgG latex agglutination inhibition method. Gel filtration of sera demonstrated high molecular weight Clq-reactive material(greater than 2 x 10(6) Daltons) which contained IgM but no IgG. Antibody titres to Onchocerca volvulus antigen were higher in patients with generalized disease than in those with the localized form. The lack of correlation between antibody titres and levels of immune complexes suggests that these immune complexes contain antigens other than those derived exclusively from the parasite. Although few of the symptoms of this disease are likely to be due to deposition of circulating immune complexes, the depression of delayed hypersensitivity reactions to the parasite found in patients with generalized onchocerciasis may be due to IgM immune complexes exerting an immuno-regulatory role on T cell function.
采用¹²⁵I-Clq结合试验在局限性和全身性盘尾丝虫病患者的血清中检测到循环免疫复合物，但IgG乳胶凝集抑制法未检测到。血清凝胶过滤显示高分子量的Clq反应性物质（大于2×10⁶道尔顿），其含有IgM但不含IgG。全身性疾病患者对盘尾丝虫抗原的抗体滴度高于局限性疾病患者。抗体滴度与免疫复合物水平之间缺乏相关性表明，这些免疫复合物所含抗原并非仅来源于寄生虫。虽然该疾病的症状很少可能是由于循环免疫复合物的沉积所致，但全身性盘尾丝虫病患者中发现的对寄生虫迟发型超敏反应的抑制可能是由于IgM免疫复合物对T细胞功能发挥免疫调节作用。
