Hong Y S, Kim S, Lotlikar P D
Toxicol Lett. 1980 Apr;5(5):345-51. doi: 10.1016/0378-4274(80)90036-3.
Differential inhibitory effects of various chemicals on both formaldehyde formation and total macromolecular binding have been examined during oxidative demethylation of [14C]dimethylnitrosamine (DMN) by hamster liver microsomes. One group of chemicals such as diethyldithiocarbamate (DEDTC), aminoacetonitrile (AAN), 2-[(2,4-dichloro-6-phenyl) phenoxy]-ethylamine (DPEA), azide and ethanol inhibits both HCHO formation and total macromolecular binding. A second group of chemicals such as reduced glutathione, semicarbazide and N-(1-naphthyl)thiourea (NTU) inhibits macromolecular binding without appreciably affecting HCHO formation. Possible mechanisms of these differential inhibitory effects by these chemicals are discussed.
在仓鼠肝微粒体对[14C]二甲基亚硝胺（DMN）进行氧化脱甲基过程中，研究了各种化学物质对甲醛形成和总大分子结合的不同抑制作用。一类化学物质，如二乙基二硫代氨基甲酸盐（DEDTC）、氨基乙腈（AAN）、2-[(2,4-二氯-6-苯基)苯氧基]-乙胺（DPEA）、叠氮化物和乙醇，对甲醛形成和总大分子结合均有抑制作用。另一类化学物质，如还原型谷胱甘肽、氨基脲和N-(1-萘基)硫脲（NTU），抑制大分子结合但对甲醛形成无明显影响。讨论了这些化学物质产生这些不同抑制作用的可能机制。
