Townsend C, Bailey J, Kohner E
Br J Ophthalmol. 1980 Jun;64(6):385-91. doi: 10.1136/bjo.64.6.385.
The results of a randomised controlled clinical study in the treatment of diabetic maculopathy are reported. Ninety-nine patients with two similarly affected eyes had one--chosen by random procedure--treated, while the other was left as an untreated control. Visual acuity was maintained in the treated eyes, while it deteriorated in the untreated eyes, reaching over 2 lines difference after 4 years. The difference in deterioration was significantly less in treated than in untreated eyes at each assessment. After 4 years the difference between the 2 eyes was greatest in those with initially good vision. There was no difference in visual acuity in patients whose initial vision was less than 6/36. Only 9 treated but 25 control eyes lost vision to blindness (P less than 0.001). It is concluded that maculopathy is a treatable form of diabetic retinopathy if treated before severe visual loss occurs.
本文报告了一项治疗糖尿病性黄斑病变的随机对照临床研究结果。99例双眼病变程度相似的患者，通过随机程序选择一只眼睛进行治疗，另一只眼睛作为未治疗的对照。治疗的眼睛视力得以维持，而未治疗的眼睛视力则恶化，4年后相差超过2行。每次评估时，治疗眼的视力恶化程度明显低于未治疗眼。4年后，最初视力良好的患者双眼差异最大。初始视力低于6/36的患者视力无差异。只有9只治疗眼但25只对照眼失明（P<0.001）。得出的结论是，如果在严重视力丧失发生之前进行治疗，黄斑病变是糖尿病视网膜病变的一种可治疗形式。
