Ohtaka M
Jpn Circ J. 1980 May;44(5):347-60. doi: 10.1253/jcj.44.347.
Spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP) were vectorcardiographically and pathologically studied for myocardial lesions with left ventricular hypertrophy, and findings were compared with those in normotensive Wistar-Kyoto rats (WK). Characteristic vectorcardiogram (VCG) in adult SHR was left superior (posterior) deviation of major QRS portion usually with ST-T changes, which corresponded to the pathological findings such as increased weight of the heart and the left ventricle. In old SHRSP, VCG showed deformity and deviation of QRS loop with prolonged P and QRS durations, and ST-T changes which corresponded to the pathological findings of myocardial degeneration or fibrosis with aggravated left ventricular hypertrophy. Such myocardial lesions were vectorcardiographically followed up in the ageing process and compared with findings in cases of induced, acute myocardial infarction. Vascular or tissue lesions of the brain, the kidney and the heart were clarified to be organ specific and to be related. Vector- or electrocardiogram are parameters for predicting cerebral stroke and/or ischemic heart diseases in humans. Primary prevention and appropriate therapy should be concomitantly considered.
对自发性高血压大鼠（SHR）和易中风SHR（SHRSP）进行了心电向量图和病理学研究，以观察其左心室肥厚的心肌病变，并将结果与正常血压的Wistar-Kyoto大鼠（WK）进行比较。成年SHR的特征性心电向量图（VCG）表现为主要QRS部分向左上（后）偏移，通常伴有ST-T改变，这与心脏和左心室重量增加等病理学发现相对应。在老年SHRSP中，VCG显示QRS环变形和偏移，P波和QRS时限延长，以及ST-T改变，这与心肌变性或纤维化伴左心室肥厚加重的病理学发现相对应。在衰老过程中通过心电向量图对这种心肌病变进行随访，并与诱导性急性心肌梗死病例的结果进行比较。明确了脑、肾和心脏的血管或组织病变具有器官特异性且相互关联。向量图或心电图是预测人类脑卒中和/或缺血性心脏病的参数。应同时考虑一级预防和适当治疗。
