Hess G, Arnold W, Meyer zum Buschenfelde K H
Klin Wochenschr. 1980 Apr 1;58(7):371-6. doi: 10.1007/BF01477280.
The Dane particle is-because of its characteristics--believed to be the complete hepatitis-B-virus. Sera containing high numbers of Dane particles were shown to be highly infectious. In the present study we related the HBeAg-, the HBsAg- and the anti-HBc titer to the level of DNA polymerase activity measured in 20 fold Dane particle concentrates. The data obtained indicate that the HBeAg concentration gives a semiquantitative estimate on the number of circulating Dane particles. Mean DNA polymerase activity was found to increase with HBsAg concentration and is therefore also of value-if determined in a HBeAg positive serum- for quantitation of Dane particles. The anti-HBc titer was found to be unrelated to the number of circulating Dane particles.
由于其特性，Dane颗粒被认为是完整的乙型肝炎病毒。含有大量Dane颗粒的血清具有高度传染性。在本研究中，我们将HBeAg、HBsAg和抗HBc滴度与在20倍Dane颗粒浓缩物中测得的DNA聚合酶活性水平相关联。所得数据表明，HBeAg浓度可对循环Dane颗粒的数量进行半定量估计。发现平均DNA聚合酶活性随HBsAg浓度增加而升高，因此，如果在HBeAg阳性血清中测定，它对于定量Dane颗粒也有价值。发现抗HBc滴度与循环Dane颗粒的数量无关。
Zotero 插件