Foglia R P, Fonkalsrud E W, Ament M E, Byrne W J, Berquist W, Siegel S C, Katz R M, Rachelefsky G S
Am J Surg. 1980 Jul;140(1):72-9. doi: 10.1016/0002-9610(80)90420-1.
Gastroesophageal reflux is a common cause of chronic pulmonary disease in children. Forty-two children with recurrent pneumonia or severe asthma were evaluated and shown to have signicant reflux. Esophagography and esophageal pH testing proved the best diagnostic tests for determining reflux. Although the pulmonary symptoms were often due to repeated aspiration, they appeared in several cases to be related to bronchospasm caused by acid in the upper esophagus. All of the children underwent Nissen fundoplication and gastrostomy an average of 30 months after the onset of pulmonary symptoms. Of the children who had preoperative pneumonia, 87 percent had no recurrence after operation. In 13 of the 14 asthmatic children who underwent operation, symptoms improved and less bronchodilator medication was required. Morbidity and mortality were closely related to the duration and severity of pulmonary disease.
胃食管反流是儿童慢性肺部疾病的常见病因。对42例复发性肺炎或重度哮喘患儿进行评估，结果显示他们存在明显的反流。食管造影和食管pH值检测被证明是确定反流的最佳诊断方法。尽管肺部症状通常是由于反复误吸所致，但在某些病例中，这些症状似乎与上段食管中的酸引起的支气管痉挛有关。所有患儿在出现肺部症状平均30个月后接受了Nissen胃底折叠术和胃造口术。术前患有肺炎的患儿中，87%术后未复发。在接受手术的14例哮喘患儿中，有13例症状改善，所需支气管扩张剂药物减少。发病率和死亡率与肺部疾病的持续时间和严重程度密切相关。
