流感病毒感染小鼠对腹腔注射或雾化吸入特定剂量利巴韦林的反应。
Response of influenza virus-infected mice to selected doses of ribavirin administered intraperitoneally or by aerosol.
作者信息
Berendt R F, Walker J S, Dominik J W, Stephen E L
出版信息
Antimicrob Agents Chemother. 1977 Jun;11(6):1069-70. doi: 10.1128/AAC.11.6.1069.
Abstract
The effects of graded doses of ribavirin administered either by aerosol or intraperitoneally were compared in influenza virus-infected mice. The median effective dose values (based upon percent survival) were 3.3 and 15.8 mg/kg per day for the aerosol and intraperitoneal routes, respectively. Lung lesion scores and titer of virus were lower after aerosol than intraperitoneal therapy.
摘要
在感染流感病毒的小鼠中，比较了通过气溶胶或腹腔注射给予不同剂量利巴韦林的效果。基于存活率的半数有效剂量值，气溶胶给药途径和腹腔给药途径分别为每天3.3毫克/千克和15.8毫克/千克。气溶胶治疗后的肺部病变评分和病毒滴度低于腹腔治疗。
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