影响人类多形核白细胞对艰难梭菌吞噬作用的因素。
Factors influencing the phagocytosis of Clostridium difficile by human polymorphonuclear leukocytes.
作者信息
Dailey D C, Kaiser A, Schloemer R H
出版信息
Infect Immun. 1987 Jul;55(7):1541-6. doi: 10.1128/iai.55.7.1541-1546.1987.
Abstract
Phagocytosis of Clostridium difficile by human polymorphonuclear leukocytes (PMNs) and the possible role of the clostridial toxins in this process were investigated. Phagocytosis of C. difficile was independent of aerobiosis and clearly depended on opsonization. Either complement or antibodies to C. difficile could serve as opsonins. Toxigenic strains of C. difficile were more resistant to phagocytosis than were nontoxigenic strains. Pretreatment of PMNs with as much as 10,000 units of toxins from culture filtrates of C. difficile for 2 h had no effect on either the phagocytic activity of PMNs or their viability as determined by trypan blue exclusion. In contrast, treatment of human embryonic intestinal cells with the same amount of toxin under identical conditions resulted in cell death.
摘要
研究了人类多形核白细胞（PMN）对艰难梭菌的吞噬作用以及梭菌毒素在此过程中可能发挥的作用。艰难梭菌的吞噬作用与需氧状态无关，且明显依赖于调理作用。补体或抗艰难梭菌抗体均可作为调理素。产毒型艰难梭菌菌株比非产毒型菌株对吞噬作用更具抗性。用高达10,000单位的来自艰难梭菌培养滤液的毒素对PMN进行2小时预处理，对PMN的吞噬活性或通过台盼蓝排斥法测定的其活力均无影响。相比之下，在相同条件下用相同量的毒素处理人胚胎肠道细胞会导致细胞死亡。
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