Schölmerich J, Kremer B, Schmidt K, Setyadharma H, Richter I E, Schoenenberger G A
Langenbecks Arch Chir. 1980;350(3):151-63. doi: 10.1007/BF01237555.
The existence of a burn toxin which could be responsible for the late burn disease has become increasingly accepted. The present study investigates both metabolism and ultrastructure of isolated rat hepatocytes both under the influence of a burn toxin isolated from burnt mouse and human skin and of its native nontoxic precursor. Cells from rats treated with toxin systematically were also investigated. The cells directly incubated with toxin showed no alterations of gluconeogenesis, but a reduced urea--and glycogensynthesis from most precursors used. Cells of pretreated rats were reduced in all functions and showed more distinct ultrastructural damage, while those incubated directly were significantly more altered. The results prove a direct toxic effect of a burn toxin on isolated liver cells.
一种可能导致烧伤后期疾病的烧伤毒素的存在已越来越被人们所接受。本研究调查了从烧伤小鼠和人类皮肤中分离出的烧伤毒素及其天然无毒前体对分离的大鼠肝细胞的代谢和超微结构的影响。还研究了经毒素全身处理的大鼠的细胞。直接用毒素孵育的细胞糖异生没有改变，但大多数所用前体的尿素和糖原合成减少。预处理大鼠的细胞所有功能均降低，超微结构损伤更明显，而直接孵育的细胞变化更显著。结果证明烧伤毒素对分离的肝细胞有直接毒性作用。
