Dreyer L
S Afr Med J. 1980 Sep 6;58(10):406-8.
Necropsy specimens of the oesophagus from 110 South African Blacks and from a control group of 110 Whites were examined for dysplasia and associated lesions of the epithelium, using the 'Swiss roll' technique. In 4 Black males (3,3%) focal areas of moderate to severe dysplasia were found. This means that the incidence of dysplasia is far higher than that of carcinoma, which seems to indicate that dysplasia is probably a reversible lesion. Parabasal cell hyperplasia was found in 44,5% of Blacks and in 29% of Whites. Keratohyaline granules in superficial epithelium also occurred more frequently in Blacks (49%) than in Whites (29%). These two conditions might be the result of chronic irritation and would probably not be significant markers in a screening programme for carcinoma. However, the presence of exfoliative dysplastic cells almost certainly indicates premalignant change in the epithelium.
采用“瑞士卷”技术，对110例南非黑人及110例白人对照组的食管尸检标本进行上皮发育异常及相关病变检查。在4名黑人男性（3.3%）中发现了中度至重度发育异常的局灶性区域。这意味着发育异常的发生率远高于癌症，这似乎表明发育异常可能是一种可逆性病变。44.5%的黑人及29%的白人中发现了基底旁细胞增生。黑人浅表上皮中的透明角质颗粒（49%）也比白人（29%）更常见。这两种情况可能是慢性刺激的结果，在癌症筛查项目中可能不是重要指标。然而，存在脱落的发育异常细胞几乎肯定表明上皮发生了癌前变化。
