Jaskiewicz K, Banach L, Mafungo V, Knobel G J
Department of Anatomical Pathology, UCT Medical School, South Africa.
Int J Cancer. 1992 Jan 2;50(1):32-5. doi: 10.1002/ijc.2910500108.
We performed post-mortem studies of oesophageal mucosa from 513 consecutive autopsies of cases who died from unnatural causes or from diseases not related to the oesophagus. Of these, 170 cases were rural blacks from endemic high-risk areas, 98 were urban blacks at high risk, 158 were coloureds at moderate risk and 87 whites at low risk for oesophageal carcinoma. Oesophagi were studied macroscopically and histologically to determine malignant and precursor lesions. A prevalence of 1.0 to 1.8% of squamous carcinoma and 7 to 7.5% of mucosal dysplasia was detected in cases older than 30 years from high-risk urban and rural population groups. These results are in accord with our previous cytological and endoscopical screening studies. No significant differences in the prevalence of oesophagitis, glycogenic acanthosis and atrophy were found in the groups studied. A study of oesophageal melanocytes showed a 3% prevalence, unrelated to dysplastic and malignant lesions, and suggested that these cells were of little if any practical significance as precursor lesions.
我们对513例死于非自然原因或与食管无关疾病的连续尸检病例的食管黏膜进行了尸检研究。其中，170例是来自地方性高风险地区的农村黑人，98例是高风险的城市黑人，158例是中度风险的有色人种，87例是食管癌低风险的白人。对食管进行了宏观和组织学研究，以确定恶性和前驱病变。在来自高风险城市和农村人群组的30岁以上病例中，检测到鳞状细胞癌的患病率为1.0%至1.8%，黏膜发育异常的患病率为7%至7.5%。这些结果与我们之前的细胞学和内镜筛查研究一致。在所研究的组中，食管炎、糖原棘皮症和萎缩的患病率没有显著差异。一项对食管黑素细胞的研究显示患病率为3%，与发育异常和恶性病变无关，并表明这些细胞作为前驱病变几乎没有实际意义。
