Rimón R, Terenius L, Kampman R
Acta Psychiatr Scand. 1980 May;61(5):395-403. doi: 10.1111/j.1600-0447.1980.tb00878.x.
Opioid-receptor-active material, endorphins, has been measured in cerebrospinal fluid samples obtained from schizophrenics. A chromatographic procedure isolated the Fraction I endorphin which was quantitated in a receptorassay. At least two cerebrospinal fluid samples were obtained from each patient, at Day 0 with no medication and at Days 30 and 60 after medication with fluphenazine under standardized conditions. Three series of patients were included: acute schizophrenics (= 11); re-entry schizophrenics (n = 7) who have previously been treated with neuroleptics but were readmitted to hospital usually as a consequence of stopped medication, and chronic schizophrenics (n = 9) who had been without neuroleptics for at least 2 weeks prior to Day 0. At Day 0, 6/9 acute cases, 4/6 of re-entry and 2/9 chronic cases had endorphin levels above the range of healthy volunteers. The levels in chronic cases were significantly lower than those in acute cases. Treatment with neuroleptics significantly lowered the endorphin levels in acute cases. These results confirm and extend previous observations.
已对从精神分裂症患者获取的脑脊液样本中的阿片受体活性物质——内啡肽进行了测定。采用一种色谱方法分离出了Ⅰ组分内啡肽，并通过受体测定法对其进行定量。在标准化条件下，从每位患者至少获取两份脑脊液样本，一份在第0天未用药时采集，另两份分别在用药氟奋乃静30天和60天后采集。研究纳入了三组患者：急性精神分裂症患者（n = 11）；再入院精神分裂症患者（n = 7），这些患者此前接受过抗精神病药物治疗，但通常因停药而再次入院；以及慢性精神分裂症患者（n = 9），这些患者在第0天前至少2周未服用抗精神病药物。在第0天，9例急性病例中有6例、6例再入院病例中有4例、9例慢性病例中有2例的内啡肽水平高于健康志愿者的范围。慢性病例的内啡肽水平显著低于急性病例。抗精神病药物治疗显著降低了急性病例的内啡肽水平。这些结果证实并扩展了先前的观察结果。
