Freire E, Snyder B
Biochim Biophys Acta. 1980 Aug 14;600(3):643-54. doi: 10.1016/0005-2736(80)90468-x.
The lateral organization of two-component phosphatidylcholine bilayers has been investigated using Monte Carlo calculations based upon non-ideality parameters deduced from the phase diagrams of these mixtures. The results are used to develop a quantitative description of the distribution and spatial localization of compositional regions along the bilayer plane in both the gel and liquid crystalline phases. In particular, a detailed analysis of the physical extension (lateral connectivity) and compactness of the compositional clusters is made. It is concluded that the chemical composition of the membrane, the physical state of the bilayer and the interaction energies between molecules greatly influence the lateral connectivity and compactness of compositional regions and that these parameters might play an important role in the formation of diffusional pathways along the membrane plane.
利用基于从这些混合物相图推导得出的非理想参数的蒙特卡罗计算方法，对双组分磷脂酰胆碱双层膜的横向组织进行了研究。这些结果被用于对凝胶相和液晶相中沿双层平面的组成区域的分布和空间定位进行定量描述。特别地，对组成簇的物理延伸（横向连通性）和致密性进行了详细分析。得出的结论是，膜的化学组成、双层膜的物理状态以及分子间的相互作用能极大地影响组成区域的横向连通性和致密性，并且这些参数可能在沿膜平面形成扩散途径中起重要作用。
