Saxton M J
Biophys J. 1982 Aug;39(2):165-73. doi: 10.1016/S0006-3495(82)84504-9.
Lateral diffusion of molecules in lipid bilayer membranes can be hindered by the presence of impermeable domains of gel-phase lipid or of proteins. Effective-medium theory and percolation theory are used to evaluate the effective lateral diffusion constant as a function of the area fraction of fluid-phase lipid and the permeability of the obstructions to the diffusing species. Applications include the estimation of the minimum fraction of fluid lipid needed for bacterial growth, and the enhancement of diffusion-controlled reactions by the channeling effect of solid patches of lipid.
脂质双层膜中分子的横向扩散会受到凝胶相脂质或蛋白质的不可渗透区域的阻碍。有效介质理论和渗流理论被用于评估有效横向扩散常数，它是液相脂质面积分数和扩散物种对障碍物渗透率的函数。应用包括估计细菌生长所需的最小液相脂质分数，以及通过脂质固体斑块的通道效应增强扩散控制反应。
