Møller B R, Märdh P A
Fertil Steril. 1980 Sep;34(3):275-9. doi: 10.1016/s0015-0282(16)44962-9.
Recently Chlamydia trachomatis has been indicated as a common cause of acute epididymitis in young men. In the present study, the grivet monkey was established as an experimental model for such infection. A yolk sac suspension of C. trachomatis, immunotype K, was inoculated into the left spermatic cords of two monkeys. On days 7 and 14 postinoculation (pi), the left testis of each monkey was enlarged to twice its normal size. The epididymis and the spermatic cord on the same side were swollen and reddened. All layers of spermatic cord were infiltrated with lymphocytes and polymorphonuclear leukocytes, and the lumen, which was filled with an exudate, was reduced in diameter. The luminar epithelium was destroyed. The ducts of the left epididymis were filled with an inflammatory exudate. The epithelium was flattened, but there were no lesions. The seminiferous tubules of the left testis were normal, but edema and hyperemia were observed in the interstitial tissue. The right spermatic cord was inoculated with noninfected yolk sac suspension. On the right side, no inflammatory reactions were seen in the testis, the epididymis, or the spermatic cord. The monkeys had a yellowish discharge 7 to 14 days pi. Urethral smears revealed an preincubation values were found.
最近，沙眼衣原体已被指出是年轻男性急性附睾炎的常见病因。在本研究中，建立了树鼩猴作为此类感染的实验模型。将免疫型K的沙眼衣原体卵黄囊悬液接种到两只猴子的左侧精索。接种后第7天和第14天，每只猴子的左侧睾丸增大至正常大小的两倍。同侧的附睾和精索肿胀、发红。精索各层均有淋巴细胞和多形核白细胞浸润，充满渗出物的管腔直径减小。管腔上皮被破坏。左侧附睾管充满炎性渗出物。上皮扁平，但无病变。左侧睾丸的生精小管正常，但间质组织观察到水肿和充血。右侧精索接种未感染的卵黄囊悬液。右侧睾丸、附睾或精索未见炎症反应。接种后7至14天，猴子出现淡黄色分泌物。尿道涂片显示未发现预孵育值。
