Angerman N S, Evans M I, Moravec W D, Schumacher G F, Hajj S N
J Reprod Med. 1980 Aug;25(2):63-6.
C-reactive protein (CRP), an acute-phase reactant not found in normal serum, has previously been shown, by qualitative assay, to differentiate inflammatory from noninflammatory pelvic pathology. In this study, quantitative measures of serum CRP were obtained concomitantly with white blood counts (WBC) and erythrocyte sedimentation rates (ESR) in patients being treated for pelvic infection. CRP levels and their changes, which were not known to physicians treating the patients, accurately indicated those patients who would need supplementary antibiotics to achieve remission. WBC levels were misleading in over half the patients, and the ESR bore no relationship to the clinical situation. The data suggest that CRP may be used to assess the efficacy of antibiotic therapy in pelvic infection. Our successful use of single-agent therapy in most cases also suggests that the use of multiple antibiotics is unnecessary and that CRP levels can indicate when additional antibiotics are appropriate.
C反应蛋白（CRP）是一种正常血清中不存在的急性期反应物，此前通过定性检测已表明，它可区分炎症性与非炎症性盆腔病变。在本研究中，对接受盆腔感染治疗的患者，同时测定了血清CRP的定量指标以及白细胞计数（WBC）和红细胞沉降率（ESR）。CRP水平及其变化（治疗患者的医生并不知晓）准确地表明了哪些患者需要补充抗生素才能实现病情缓解。超过半数患者的WBC水平具有误导性，且ESR与临床情况无关。数据表明，CRP可用于评估盆腔感染中抗生素治疗的疗效。我们在大多数病例中成功使用单药治疗还表明，使用多种抗生素并无必要，且CRP水平能够指示何时需要追加抗生素。
