Perocco P, Fini A
Tumori. 1980 Aug 31;66(4):425-30. doi: 10.1177/030089168006600403.
The action of dichlorvos (2,2-dichlorovinyldimethyl phosphate) was studied with a short-term in vitro system which utilizes lymphocytes. The parameters studied were the action exerted by the pesticide on scheduled (semiconservative) and unscheduled (reparative) DNA synthesis measured as tritiated thymidine uptake. The results obtained show that dischlovos affects semiconservative DNA synthesis, damages human lymphocyte DNA inducing low reparative synthesis, and interferes with DNA repair processes after damage exerted by ultraviolet rays.
使用一个利用淋巴细胞的短期体外系统研究了敌敌畏（2,2 - 二氯乙烯基二甲基磷酸酯）的作用。所研究的参数包括该农药对以氚化胸腺嘧啶摄取量衡量的程序性（半保留）和非程序性（修复性）DNA合成所产生的作用。所得结果表明，敌敌畏影响半保留DNA合成，损害人类淋巴细胞DNA，诱导低水平的修复性合成，并干扰紫外线造成损伤后的DNA修复过程。
