Gol'bert Z V, Sorkin E E, Frank G A
Vopr Onkol. 1978;24(11):58-64.
During the recent ten-year period lobular cancer of the mammary gland arrests special interest. It is characterized by a specific clinical course, frequent bilateral involvement of the glands, multicentric and manifest invasive growth without any noticeable signs of destruction of the pre-existing glandular tissue. This cancer is preceded by carcinoma in situ. In the paper, the necessity is substantiated to differentiate this kind of cancer as a special nosological unit, its peculiar structure being described. Besides the classical form of the growth from small homologous cells like chains, also there was found a special form of the growth as alveolar structures consisting of light pagetoid cells. The initial stages of lobular cancer growth are described both against the background of carcinoma in situ and avoiding it from dysplasia. Attention is given to a tendency of this cancer to mucicarminophilia, a frequent association with mucous cancer, the data speaking in favour of its myoepithelial origin are reported. It is emphasized that carcinoma in situ may give rise both to lobular (myoepithelial origin) and other forms of cancer.
在最近十年间，乳腺小叶癌引起了特别关注。它具有特定的临床病程，腺体常双侧受累，呈多中心性且有明显的浸润性生长，而先前存在的腺组织却没有任何明显的破坏迹象。这种癌症之前存在原位癌。本文论证了将这种癌症作为一个特殊的病种单位进行区分的必要性，并描述了其独特的结构。除了经典的由小的同源细胞呈链状生长的形式外，还发现了一种特殊的生长形式，即由淡染的派杰样细胞组成的腺泡结构。小叶癌生长的初始阶段在原位癌背景下以及不考虑发育异常的情况下均有描述。文中关注了这种癌症的黏液卡红嗜色性倾向、与黏液癌的频繁关联，并报告了支持其肌上皮起源的数据。强调原位癌可能引发小叶癌（肌上皮起源）以及其他形式的癌症。
