Philpott D E, Corbett R, Turnbill C, Black S, Dayhoff D, McGourty J, Lee R, Harrison G, Savick L
Aviat Space Environ Med. 1980 Jun;51(6):556-62.
Ten rats, five centrifuged during flight to simulate gravity and five stationary in flight and experiencing hypogravity, orbited the Earth. No differences were noted between flight-stationary and flight-centrifuged animals, but changes were seen between these two groups and ground controls. Morphological alterations were observed comparable to those in the experiment flown on Cosmos 782 and to the retinal cells exposed to high-energy particles at Berkeley. Affected cells in the outer nuclear layer showed swelling, clearing of cytoplasm, and disruption of the membranes. Tissue channels were again found, similar to those seen on 782. After space flight, preliminary data indicated an increase in cell size in montages of the nuclear layer of both groups of flight animals. This experiment shows that weightlessness and environmental conditions other than cosmic radiation do not contribute to the observed damage of retinal cells.
十只大鼠环绕地球飞行，其中五只在飞行过程中进行离心以模拟重力，另外五只在飞行中静止并经历微重力环境。飞行静止组和飞行离心组动物之间未发现差异，但这两组与地面对照组之间出现了变化。观察到的形态学改变与在“宇宙782号”上进行的实验以及在伯克利暴露于高能粒子的视网膜细胞中的改变相当。外核层中受影响的细胞出现肿胀、细胞质澄清和细胞膜破裂。再次发现了组织通道，类似于在“宇宙782号”上看到的那些。太空飞行后，初步数据表明两组飞行动物核层蒙片中的细胞大小增加。该实验表明，失重和宇宙辐射以外的环境条件不会导致观察到的视网膜细胞损伤。
