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城市烟雾提取物的生物学效应分析。VI. 城市烟雾提取物及其组分对仓鼠肾细胞、胚胎细胞和灵长类动物埃塞俄比亚猕猴肾细胞DNA合成影响的比较研究（作者译）

[Analysis of the biological effect of city smog extract. VI. Comparative investigations on the effect of city smog extracts and their fractions on DNA synthesis of hamster kidney and embryonic cells and kidney cells of the primate Cercopithecus aethiops (author's transl)].

作者信息

Krampitz G, Seemayer N

出版信息

Zentralbl Bakteriol B Hyg Krankenhaushyg Betriebshyg Prav Med. 1980 Feb;170(1-2):1-16.

PMID:7424254
Abstract

We analyzed the effect of two samples of city smog extracts and their fractions from Duisburg on the rate of DNA synthesis of mammalian cell cultures. - We employed tissue cultures of kidney and embryonic cells from the Syrian golden hamster (Cricetus aureatus) and kidney cells from the African green monkey (Cercopithecus aethiops). The DNA synthesis was determined autoradiographically after incubation with 3H-thymidine. We found that both city smog extracts exerted a dose-dependent suppression of cellular DNA synthesis. Monkey kidney cells were more sensitive than rodent cells. Analysis of single fractions indicate that the inhibition of DNA synthesis is the result of combined effects of all fractions. At present time it is not possible to correlate the toxic effect of the complete extract special to a single fraction or compound group.

摘要

我们分析了来自杜伊斯堡的两份城市烟雾提取物及其馏分对哺乳动物细胞培养物中DNA合成速率的影响。我们采用了叙利亚金仓鼠（金黄地鼠）的肾组织培养物和胚胎细胞以及非洲绿猴（非洲长尾猴）的肾细胞。在用³H-胸腺嘧啶核苷孵育后，通过放射自显影法测定DNA合成。我们发现，两种城市烟雾提取物均对细胞DNA合成产生剂量依赖性抑制。猴肾细胞比啮齿动物细胞更敏感。对单一馏分的分析表明，DNA合成的抑制是所有馏分共同作用的结果。目前，尚无法将完整提取物的毒性作用与单一馏分或化合物组联系起来。

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