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变形链球菌葡糖基转移酶与抗体的相互作用

Interaction of Streptococcus mutans glucosyltransferases with antibodies.

作者信息

Kuramitsu H K, Ingersoll L

出版信息

Adv Exp Med Biol. 1978;107:727-36. doi: 10.1007/978-1-4684-3369-2_82.

Abstract
  1. The GTF-A and GTF-B activities of serotype (c), (e), and (f) organisms are antigenically more closely related to each other than to the comparable enzymes from organisms of the other four S. mutans serotypes. 2) The adherence-inhibiting antibody in anti-GTF-A appears to be mediated against a heat sensitive cell surface antigen of S. mutans - most likely GTF activity. However, unequivocal proof of this conclusion awaits the preparations of homogeneous GTF-A preparations.
摘要

1)血清型(c)、(e)和(f)菌株的葡糖基转移酶A(GTF-A)和葡糖基转移酶B(GTF-B)活性在抗原性上彼此之间的关系比与其他四种变形链球菌血清型菌株的相应酶更为密切。2)抗GTF-A中的黏附抑制抗体似乎是针对变形链球菌的一种热敏感细胞表面抗原介导的——很可能是GTF活性。然而,这一结论的确切证据有待于制备出纯一的GTF-A制剂。

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