Dutt M K, Thompson R P
J R Soc Med. 1982 Apr;75(4):231-3. doi: 10.1177/014107688207500404.
Five hundred outpatients undergoing endoscopy were admitted into a controlled trial comparing the incidence of thrombophlebitis following intravenous diazepam administered in the way, with the effects of either a saline flush following the diazepam or diluting the drug with the patient's own blood before injection ('barbotage'). The results were assessed using a questionnaire completed by patients two weeks after endoscopy; 80% replied. A saline flush reduced the incidence of side effects, particularly pain (P less than 0.05). 'Barbotage' gave the highest incidence of side effects. Saline flush is therefore recommended as a means of reducing the thrombophlebitis which may follow intravenous diazepam.
五百名接受内窥镜检查的门诊患者被纳入一项对照试验，比较以该方式静脉注射地西泮后血栓性静脉炎的发生率，以及地西泮后用生理盐水冲洗或在注射前用患者自身血液稀释药物（“回抽法”）的效果。在内窥镜检查两周后，通过患者填写的问卷对结果进行评估；80%的患者进行了回复。生理盐水冲洗降低了副作用的发生率，尤其是疼痛（P<0.05）。“回抽法”产生的副作用发生率最高。因此，建议使用生理盐水冲洗来降低静脉注射地西泮后可能出现的血栓性静脉炎。
