Mattila M A, Ruoppi M, Korhonen M, Larni H M, Valtonen L, Heikkinen H
Br J Anaesth. 1979 Sep;51(9):891-4. doi: 10.1093/bja/51.9.891.
In 104 patients undergoing anaesthesia of short duration, two different solvents, propylene glycol and cremophor, were compared in a double-blind trial. Diazepam 10 mg in a coded solution was injected into a superficial vein of the hand using a small-gauge needle. The vein was examined after 14 days. The frequency of thrombophlebitis with propylene glycol was 62.2% and with cremophor 3.4% (P less than 0.001). The frequency of pain on injection was also in favour of the new solvent (P less than 0.001). The possibility of anaphylactic reactions accredited to cremophor, however, restricts the use of the new injection.
在104例接受短时间麻醉的患者中，在一项双盲试验中比较了两种不同的溶剂，丙二醇和聚氧乙烯蓖麻油。将10毫克地西泮溶于编码溶液中，用细针头注入手部浅静脉。14天后检查静脉。丙二醇引起血栓性静脉炎的发生率为62.2%，聚氧乙烯蓖麻油为3.4%（P<0.001）。注射时的疼痛发生率也有利于新溶剂（P<0.001）。然而，聚氧乙烯蓖麻油引起过敏反应的可能性限制了这种新注射液的使用。
