Currie G A, Hedley D W
Br J Cancer. 1977 Jul;36(1):1-6. doi: 10.1038/bjc.1977.147.
A micro-assay designed to assess the capacity of peripheral blood mononuclear cells to differentiate in vitro into mature macrophages is described. In patients with "final common pathway" malignant melanoma, there was a highly significant deficiency in macrophage precursors (MPs). By conventional morphological criteria such patients did not show a significant monocytopenia. Serum factors do not seem to contribute to the MP defect in the patients. We conclude that these patients have an intrinsic functional defect in their peripheral blood monocytes, but the mechanisms responsible for this defect are as yet unknown.
本文描述了一种用于评估外周血单核细胞在体外分化为成熟巨噬细胞能力的微量分析方法。在患有“最终共同途径”恶性黑色素瘤的患者中，巨噬细胞前体（MPs）存在高度显著的缺陷。按照传统形态学标准，此类患者并未出现明显的单核细胞减少。血清因子似乎并非导致患者MP缺陷的原因。我们得出结论，这些患者外周血单核细胞存在内在功能缺陷，但其缺陷产生的机制尚不清楚。
