Fraser R, Bowler L M, Day W A, Dobbs B, Johnson H D, Lee D
Br J Exp Pathol. 1980 Apr;61(2):222-8.
Fenestrated endothelium lining liver sinusoids forms an ultrastructural sieve between blood and hepatocytes which at physiological perfusion pressures has previously been shown to shield hepatocytes from large triglyceride-rich chylomicrons. In the study reported in this paper, enlargement of endothelial fenestrae at high perfusion pressures has been confirmed and a concurrent increase in trapping of large chylomicrons by the liver noted. These findings suggest the importance of employing physiological perfusion pressures in studies designed to examine hepatic lipoprotein metabolism and also suggest a possible mechanism in the pathogenesis of fatty change seen in the "nutmeg" liver of chronic venous congestion.
肝血窦内衬的有孔内皮在血液和肝细胞之间形成了一个超微结构筛网，在生理灌注压力下，先前已证明该筛网可保护肝细胞免受富含甘油三酯的大乳糜微粒的影响。在本文报道的研究中，已证实高灌注压力下内皮窗孔会扩大，同时还发现肝脏对大乳糜微粒的捕获量增加。这些发现表明，在旨在研究肝脏脂蛋白代谢的研究中采用生理灌注压力非常重要，也提示了慢性静脉淤血“槟榔肝”中所见脂肪变性发病机制的一种可能机制。
