数学建模在野外研究中评估铬和镍生物半衰期的应用。
Application of mathematical modelling for assessing the biological half-times of chromium and nickel in field studies.
作者信息
Tossavainen A, Nurminen M, Mutanen P, Tola S
出版信息
Br J Ind Med. 1980 Aug;37(3):285-91. doi: 10.1136/oem.37.3.285.
Abstract
The biological half-times of urinary chromium and nickel excretion and plasma nickel concentration were calculated for four welders and four electroplaters. A linear one-compartment kinetic model gave estimates of the half-times ranging from 15 to 41 hours for chromium in urine, from 17 to 39 hours for nickel in urine, and from 20 to 34 hours for nickel in plasma. The model allows a precise description to be made of a worker's state of exposure as affected by a varying concentration of the metals in the air.
摘要
计算了4名焊工和4名电镀工人尿中铬和镍的排泄以及血浆镍浓度的生物半衰期。线性单室动力学模型得出的半衰期估计值为：尿中铬为15至41小时，尿中镍为17至39小时，血浆中镍为20至34小时。该模型能够精确描述工人的暴露状态，这种状态受空气中金属浓度变化的影响。
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