金黄色葡萄球菌临床分离株对氨基糖苷类抗生素的厌氧耐药性。
Anaerobic resistance of clinical isolates of Staphylococcus aureus to aminoglycosides.
作者信息
Harrell L J, Evans J B
出版信息
Antimicrob Agents Chemother. 1978 Dec;14(6):927-9. doi: 10.1128/AAC.14.6.927.
Abstract
The anaerobic minimum inhibitory concentration of six aminoglycosides (amikacin, gentamicin, kanamycin, netilmicin, sisomicin, and tobramycin) averaged over 10-fold greater than the aerobic minimum inhibitory concentration for 50 clinical isolates of Staphylococcus aureus. Cultures from osteomyelitis and blood generally showed a somewhat greater increase in minimum inhibitory concentration due to anaerobiosis than did cultures from abscesses and wounds, and amikacin activity was most affected by anaerobiosis.
摘要
对于50株金黄色葡萄球菌临床分离株，六种氨基糖苷类药物（阿米卡星、庆大霉素、卡那霉素、奈替米星、西索米星和妥布霉素）的厌氧最低抑菌浓度平均比需氧最低抑菌浓度高10倍以上。来自骨髓炎和血液的培养物因厌氧导致的最低抑菌浓度增加幅度通常比来自脓肿和伤口的培养物更大，且阿米卡星的活性受厌氧影响最大。
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