四种大鼠免疫球蛋白同种型的生物学半衰期。
The biological half-lives of four rat immunoglobulin isotypes.
作者信息
Peppard J V, Orlans E
出版信息
Immunology. 1980 Aug;40(4):683-6.
Abstract
Purified preparations of monoclonal rat IgG2a, IgG1, IgM and monomeric IgA, and of polyclonal IgG, were lightly radiolabelled with 125I and injected intravenously into rats. Blood samples were taken so that the half-life of each immunoglobulin isotype could be calculated. Half-life was defined as the time taken for the specific radioactivity present in the blood 24 h after injection to fall by half. The half-life values thus obtained were 106 h for IgG2a, 53 h for IgG1, 63 h for polyclonal IgG, 25 h for IgM and 27 h for monomeric IgA.
摘要
将单克隆大鼠IgG2a、IgG1、IgM和单体IgA以及多克隆IgG的纯化制剂用125I进行轻度放射性标记，然后静脉注射到大鼠体内。采集血样以计算每种免疫球蛋白同种型的半衰期。半衰期定义为注射后24小时血液中存在的比放射性下降一半所需的时间。由此获得的半衰期值分别为：IgG2a为106小时，IgG1为53小时，多克隆IgG为63小时，IgM为25小时，单体IgA为27小时。
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